PCDHGC3, a member of the PCDHγ cluster, has been described in previous studies as a tumor suppressor that promotes the apoptosis of tumor cells, as well as suppresses the Wnt- and mTOR-signaling pathways, which negatively affects the growth of various tumors such as Wilms tumors, breast cancer, or prostate cancer [20]. Here, PCDHGC3 is linked to Familial prostate cancer.