As CaV1.2 is also expressed in pancreatic beta cells and the patient with the CaV1.2L566P mutation suffered from hyperinsulinemic hypoglycemia, we further investigated the effects of the two mutations (CaV1.2G406R and CaV1.2L566P) on electrophysiology in an in silico model of human beta cells by Riz et al. [18]. Here, CACNA1C is linked to hyperinsulinemic hypoglycemia.