Moreover, in a recent study that examined the pathophysiological effect of CRP itself as a mediator of tissue damage in acute myocardial infarction, Ries et al. explored the usage of CRP apheresis in patients aiming to investigate the relationship between CRP gradient and the myocardial infarct size and function in the setting of acute STEMI as well as the effect of CRP apheresis efficacy [36]. Here, CRP is linked to acute myocardial infarction.