KCNA1 and Global developmental delay: Trying to draw a correlation between epilepsy phenotype and mutation localization in KCNA1 diseases, it appears that KCNA1 pore mutations affecting the selectivity filter or the proline residues in the PVP motif are associated with epileptic phenotypes aggravated by developmental delay and sometimes drug-resistance, whereas aminoacidic substitutions outside the pore and the PVP domain (such as A261T, S3) seem to occur in patients with milder epileptic phenotypes, usually with a favorable seizure outcome and without intellectual disability [7,30,31] (Table S1).