As mentioned before, genetic variants in both KCNA1 and KCNA2, which disrupt the proline residues of the PVP motif, have been identified in children with severe epilepsy and comorbidities (P403S and P405S/L in Kv1.1 and P405L and P407A in Kv1.2; Table S1). The gene discussed is KCNA1; the disease is epilepsy.