Xiaoduo Zhao and co-workers highlighted not only an upregulation of Piezo1 protein expression associated with renal fibrosis (also confirmed by TGF-β stimulation), but also a reduction in fibrotic markers such as fibronectin, collagen I, TGF-β, α-SMA by using the non-specific Piezo1 inhibitor GsMTx4. Here, PIEZO1 is linked to renal fibrosis.