ADCYAP1R1 and migraine disorder: The PAC1R is involved in the regulation of pleiotropic neurological functions including promotion of neural survival and synaptic plasticity, nociceptive pain, and regulating the hypothalamic–pituitary–adrenal axial stress response, which makes it an attractive target for nervous system disorders including migraine [85,102,103], secondary injury in traumatic brain injury [84], and post-traumatic stress disorder [81,83].