Besides, a highly significant elevation was recorded in the waist/hip, cholesterol, low-density lipoprotein cholesterol (LDL-C), fasting glucose, LH, LH/FSH ratio, estradiol (E2), and testosterone, while hip circumference, leptin, progesterone, and sex hormone binding globulin (SHBG) were lower in the obese PCOS subjects [57]. This evidence concerns the gene SHBG and polycystic ovary syndrome.