CASP1 and mevalonic aciduria: Recently, studies conducted by Skinner et al., have clearly shown that the loss of prenylation of some GTPases, such as Rac1 or RhoA, leads to the activation of inflammasome and thus of caspase 1, with increased production of IL1β; this has been observed in both human monocytic cells treated pharmacologically with statins, and directly in cells of patients suffering from MKD, upon stimulation with LPS [65].