The overproduction of IL-1β in MKD syndromes, linked to neuroinflammation, fever, and oxidative stress, is thus considered a causal factor and is the reason anti-IL-1 therapeutic approaches (anakinra, canakinumab) have been approved for MKD treatment and have been reported to be at least partially effective in some patients [25,61,107,108]. Here, IL1B is linked to mevalonic aciduria.