CASP1 and mevalonic aciduria: In diseases associated with prenylation defects such as MKD, the typical neurodegeneration has been reported to be linked to both caspase-9/3-dependent apoptosis, triggered by mitochondrial damage, and to pyroptosis mediated by caspase-1, which in turn activates cytokines and pro-inflammatory chemokines, playing a crucial role in neuroinflammatory mechanisms [90,105,106].