MVK and mevalonic aciduria: It has been proposed that the excessive production of IL1β observed in patients with MKD, suffering from the congenital deficiency of the enzymatic activity of MVK [61], could be caused by the loss of protein prenylation, in particular when GGPP is missing; this event favors an overactivation of the inflammasome, thus triggering the systemic inflammatory peaks characteristic of the pathology [62,63].