Targeted NGS on 69 tumor, 23 dysplasia, and three indefinite for dysplasia samples revealed mutations in 13 genes: ARID1A, NRAS, ELF3, IDH1, PIK3CA, APC, KMT2C, KRAS, TP53, ERBB2, SMAD4, CDKN2A, and GNAS. The gene discussed is APC; the disease is neoplasm.