The results showed that in children with SLE serum RANKL was positively correlated with the duration of SLE and the cumulative dose of GC (*P < 0.05), and was negatively correlated with serum OPG and 25(OH) VitD3 (*P < 0.05), while not correlated with height, weight, BMI and age (P > 0.05). Here, TNFSF11 is linked to systemic lupus erythematosus.