NONO-TFE3 translocation renal cell carcinoma (NONO-TFE3 tRCC) is one of the subtypes of Xp11.2 translocation/TFE3 fusion-associated renal cell carcinoma (Xp11.2 tRCC), which is also known as TFE3-fusion associated RCC as a new subset of RCC by WHO in 2016 [1, 2]. The gene discussed is TFE3; the disease is renal cell carcinoma.