TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: To delve further into one potential function of the HNRNPK in tumor progression of NONO-TFE3 tRCC, we constructed a dCas9-based system to recruit HNRNPK to the TRAF3IP2 promoter by MS2-loop on gRNA.