A dCas9-based system designed to recruit SETDB1 to the TRAF3IP2 promoter was constructed to clarify the function of the SETDB1 in the progression of NONO-TFE3 tRCC. This evidence concerns the gene TRAF3IP2 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.