Furthermore, the results of colony formation, tumor sphere formation, EdU, flow cytometry, and Transwell assays revealed that cell proliferation, cell cycle, migration, and invasion were enhanced by transfection with gTRAF3IP2 combined with dCas9-DNMT1 compared with the negative control in UOK109 cells (Figure S6B-I, S6L-M). Here, DNMT1 is linked to neoplasm.