High expression of TRAF3IP2 was caused by the low expression of TRAF3IP2-AS1 via DNA/Histone modification and promoted the development of NONO-TFE3 tRCC (Fig. 6P). This evidence concerns the gene TRAF3IP2 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.