The typical feature of Xp11.2 tRCC is the high expression of TFE3 fusions caused by the promoter region of partner genes, including ASPL, PRCC, NONO, CLTC, and other housekeeping genes [3–5]. This evidence concerns the gene NONO and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.