Taken together, these results indicate that TRAF3IP2-AS1 mediates NONO-TFE3 tRCC progression by recruiting HNRNPK to the promoter region of TRAF3IP2 to suppress the expression of TRAF3IP2. The gene discussed is TRAF3IP2; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.