Taken together, these results indicate that TRAF3IP2-AS1 mediates NONO-TFE3 tRCC progression by recruiting HNRNPK to the promoter region of TRAF3IP2 to suppress the expression of TRAF3IP2. Here, NONO is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.