Taken together, these results indicate that TRAF3IP2-AS1 mediates NONO-TFE3 tRCC progression by recruiting HNRNPK to the promoter region of TRAF3IP2 to suppress the expression of TRAF3IP2. This evidence concerns the gene HNRNPK and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.