ABI3 and Alzheimer disease: Using RNAseq data from the AMP-AD consortium, we investigated the concordance between the expression patterns of Abi3 and Gngt2. We found that ABI3 and GNGT2 genes were co-regulated in three distinct AD patient cohorts: temporal cortex samples of Mayo Clinic AD cohort (Mayo TCX: ρ = 0.644, p = 2.2e − 16) (Fig. 2a), cerebellar samples of Mayo Clinic AD cohort (Mayo CER: ρ = 0.556, p = 2.2e − 16) (Fig. 2b) and prefrontal cortex samples of Religious Orders Study and Rush Memory and Aging Project AD cohort (ROSMAP; ρ = 0.328, p = 2.2e − 16) (Fig. 2c).