GLS and neoplasm: Tumor cells transport glutamine into cells through specific transporters (such as solute carrier family 1 neutral amino acid transporter member 5, SLC1A5; also known as alanine, serine, cysteine-preferring transporter 2, ASCT2), and then convert it into glutamate under the action of glutaminase (GLS), and further convert it into α-ketoglutarate (α-KG), which enters the Tricarboxylic Acid cycle (TCA) and participates in the onset, development and dissemination of tumors [21, 22].