These regulatory molecules are often oncogenes or tumor suppressors that abnormally expressed in the tumors, and involved in tumor initiation and progression, such as Myc, p53, Ras, Hypoxia-inducible factor (HIF), Rho GTPase, etc. The above oncogenes or proteins may play a role in abnormal glutamine metabolism in the TME. This evidence concerns the gene TP53 and neoplasm.