PROS1 and cardiovascular disorder: It has been reported that psychological stress activates hypothalamic–pituitary–adrenal axis activity and increases the levels of glucocorticoid hormones, causes damage to hippocampal structure and function [33], affects learning and memory processes [34], increases the deposition of β-amyloid peptid and τ-protein [35] in the brain and increases the incidence of cardiovascular disease [36] and hypertension [37].