OVO‐like zinc finger 2 (OVOL2), a member of the OVO family of conserved zinc‐finger transcription factors, can regulate embryonic development and cancer metastasis.[11, 12, 13, 14, 15, 16, 17] It has been reported that Ovol2 gene knockout (KO) in mice results in embryonic lethality before embryonic day 10.5, indicating that OVOL2 is involved in early embryonic development.[11] OVOL2 expression was shown to be downregulated in hepatocellular carcinoma and colorectal cancer.[13, 14] Decreased OVOL2 expression predicts poor clinical outcomes. This evidence concerns the gene OVOL2 and cancer.