Interestingly, OVOL2 KO‐mediated promotion of proliferation and invasion was almost abolished by the glycolytic inhibitor 2‐deoxy‐D‐glucose (2‐DG) and KD of PKM2, a rate‐limiting glycolytic enzyme (Figure 5C,D and Figure S5D,E, Supporting Information), suggesting that glycolysis is responsible for OVOL2‐mediated modulation of cancer cell proliferation and invasion. The gene discussed is OVOL2; the disease is cancer.