It should be noted that hypoxia‐mediated induction of p53 did not occur in a mutant hepatoma cell line that failed to stimulate HIF1α or embryonic stem cells derived from mice lacking HIF1α,[40] suggesting that the hypoxic induction of p53 is HIF1α‐and cell type‐dependent. The gene discussed is HIF1A; the disease is hepatocellular carcinoma.