Considering that the Kd between whole chromogranins and NE is 2.1 mM and one major chromogranin, CgA, binds to fivefold NE molecules,[25, 29] we suggest that the weak ≈250 mM binding affinity between SgII and NE does not contribute to large NE storage in LDCVs, which excludes the possibility of catecholamine deficiency in SgII‐KD ACCs. The gene discussed is SCG2; the disease is hyperinsulinemic hypoglycemia, familial, 4.