CGA and hyperinsulinemic hypoglycemia, familial, 4: Considering that the Kd between whole chromogranins and NE is 2.1 mM and one major chromogranin, CgA, binds to fivefold NE molecules,[25, 29] we suggest that the weak ≈250 mM binding affinity between SgII and NE does not contribute to large NE storage in LDCVs, which excludes the possibility of catecholamine deficiency in SgII‐KD ACCs.