Many authors proposed their own definition of DKD, and almost all of them agreed with the ISPAD 2018 guidelines [5], in which the beginning of DKD is associated with the development of microalbuminuria (albumin excretion rate between 30 and 300 mg/24 h or 20 and 200 μg/min in a 24-h or timed urine collection). The gene discussed is ALB; the disease is diabetic kidney disease.