We measured the BMI, WHR and BFM of 215 subjects to determine the relationship between these obesity indicators and Fetuin B. Of interest, only BFM, but not BMI or WHR, was positively correlated with Fetuin B. Importantly, as stated by our previous population-based study and other research groups, Fetuin B has been widely demonstrated to participate in regulating insulin resistance, glucose intolerance and steatosis in the liver13,17–19,58. This evidence concerns the gene FETUB and obesity due to melanocortin 4 receptor deficiency.