TP53 and malignant colon neoplasm: In addition, activation of the AMPK-SIRT1-p53 pathway increases the phosphorylation of ACC in A549 and NCI-H1299 cells [35], while downregulation of p53 increases G6PD activity in colon cancer [36], which leads us to establish a relationship between LKB1-AMPK signaling and p53-mediated G6PD regulation.