Interestingly, in our study, immunoassay results for the hub genes were highly concordant, manifesting prominent positive correlations with NK CD56bright cell and Tfh cell types, prominent negative correlations with macrophage as well as B7H3, PDCD1, LAG3 and CXCL16, CXCR4, CCR5, which revealed for the first time the possible immunological effects of ATP6V1G2, GABARAPL1, and GOT1 in cancer. This evidence concerns the gene CD276 and cancer.