For example, we have shown using our home-cage chambers that mice with Scn1a mutations36 (modeling Dravet syndrome) display nocturnal hypoactivity, hypersomnia and hypodipsia20, while mice prenatally exposed to valproic acid exhibit hypophagia and increased wheel-running without changes in sleep and activity. The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.