For examples, human PRSS1 (cationic trypsinogen) is one of the EV-A71 IRES-associated proteins in human glioblastoma T98G cells and the cleavage of hemagglutinin (HA) by activated human trypsinogen (PRSS3) enhanced influenza A virus infection44,45. This evidence concerns the gene PRSS1 and glioblastoma.