It is also interesting to note that while a significant proportion of IL12RB1 patients develop candidiasis, it is relatively more common, severe and chronic in patients with RORC deficiencies22,26–28; this may correlate with the greater impacts on both ILCP and ILC3 generation seen in RORγT-deficient patients compared to IL12RB1-deficient patients. The gene discussed is RORC; the disease is candidiasis.