PRPF8 and cancer: The ABL1-I418T, PIK3CB-R231H, CHEK2:c.-4C > T, BRCA2-P3292L, ABL1-E459G, PRPF8-G1796R, PHF6-R274Q, WT1-R435X and ATM-C117Y variants were potentially important cancer variants which were not actionable (Table 3).