IKZF1 mutations had been found in both chronic and blastic phase CML24.The patient with IKZF1 mutation also had a mutation in PTPN11. It has been shown that in AML patients, mutations in IKZF1 and PTPN11 are associated with aggressive clinical course and primary resistant to chemotherapy25. This evidence concerns the gene PTPN11 and acute myeloid leukemia.