Furthermore, a KEGG pathway annotation analysis of differentially regulated genes associated with HFD identified a number of relevant pathways, most notably hypertrophic cardiomyopathy, pro-angiogenic apelin signaling, vascular smooth muscle contraction, and dilated cardiomyopathy (DCM; Fig. 3G, right panel). This evidence concerns the gene APLN and familial dilated cardiomyopathy.