We see a significant association of PLIN1 pLOF with decreased triglycerides (P = 9.56 × 10−12, Beta = −0.26 SD), a nominally significant association with decreased blood pressure (P = 0.02 for diastolic blood pressure, P = 0.03 for systolic blood pressure) and a lower odds ratio for T2D (P = 0.11, OR = 0.81, 95% CI 0.62 to 1.05) opposite to the lipodystrophy phenotype. The gene discussed is PLIN1; the disease is lipodystrophy.