PLIN1 variants resulting in a longer protein containing 158 aberrant amino acids (frameshift variants rs1567075176 and rs1567075667) have been shown to cause familial partial lipodystrophy type 4 (FPLD4), characterized by a loss of subcutaneous adipose tissue particularly in the gluteal region and lower limbs, hypertriglyceridemia, hypertension, and type 2 diabetes23. The gene discussed is PLIN1; the disease is hypertriglyceridemia.