We then used this system to characterize the most common INHBE pLOF variants in UKB, the splice acceptor rs150777893 (NM_031479.4:c.299-1 G > C) and the splice donor rs375342858 (NM_031479.4:c.298 + 1 G > T), as well as rs146517777 (p.Tyr253Ter) found in the AMP-T2D-GENES analysis (Fig. 5a). The gene discussed is INHBE; the disease is type 2 diabetes mellitus.