Consistent with this, we see fewer cases of CHD (P = 0.05, OR = 0.78, 95% CI 0.60 to 1.00) and T2D (P = 0.65, OR = 0.94, 95% CI 0.70 to 1.24) for INHBE pLOF carriers compared to non-carriers which, notably, are proportional to the effect on WHRadjBMI based on estimates from MR1 (Fig. 3). Here, INHBE is linked to type 2 diabetes mellitus.