Later, Zhao et al. leveraged ImmunoChip data from European and East Asian populations to further characterize the GTF2IRD1-GTF2I locus in systemic lupus erythematosus (SLE) and Sjögren’s, discovering a missense mutation in Neutrophil cytosolic factor 1 (NCF1) (pArg90His) that decreases reactive oxygen species production and predisposes individuals to Sjögren’s and other autoimmune diseases18. The gene discussed is NCF1; the disease is systemic lupus erythematosus.