This analysis parallel with the findings of anotherMendelian randomization study that suggested an association of lower levels of ACE(messenger RNA and protein) with decreased systolic blood pressure (SBP) on one side, andwith an increased risk of schizophrenia on the other side.279 There was no evidence for an association betweengenetically estimated SBP and schizophrenia risk, suggesting that any association of ACEwith schizophrenia is presumably independent of its association with blood pressure. This evidence concerns the gene ACE and schizophrenia.