By contrast, it is unclear that this TP53‐dependency is associated to lower signalling levels of endogenous VAV1ΔC as we found quite similar transcriptomal changes in the lymphoma cells obtained from Trp53ER/ER;Vav1ΔC/ΔC mice and adoptively transferred VAV1ΔC‐expressing CD4+ cells. Here, TP53 is linked to lymphoma.