Given that the loss of the TP53 gene is a common event in NSCLC and some PTCL subtypes [28, 42, 43, 44], we decided to evaluate whether the loss of this tumour suppressor gene could synergize with the gain‐of‐function Vav1 mutation in tumour formation. The gene discussed is VAV1; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.