Pan et al. overexpressed the T/NK cells-targeting chemokine CXCL9 and the immunostimulatory factor OX40 ligand (OX40L) in MSCs by lentiviral transfection, which increased the proportion of infiltrating CD8 + T and NK cells in colon cancer tumors, the production of antitumor cytokines and cytolytic proteins in the tumor microenvironment, thus overcoming the systemic toxicity of therapeutic agents and the problem of low lymphocyte infiltration in solid tumors [605]. Here, CD8A is linked to neoplasm.