TNF and autoimmune hepatitis: It was shown that miR-223 in BM-MSCs-exos reversed liver inflammation and cell death by downregulating mRNA and protein levels of NLRP3 and caspase-1 in an experimental AIH model, while decreasing levels of pro-inflammatory cytokines (TNF-α, IL-17A and IL-1β) in serum and liver tissues [440].