Recent studies have found that fatty liver microenvironment-induced autoaggressive CXCR6 + CD8 + T cell subsets, unlike antigen-specific CD8 + T cells, can promote liver injury and conversion of NASH to HCC by secreting pro-inflammatory cytokines and directly killing hepatocytes in a FASL-dependent and TNF-dependent manner [198]. This evidence concerns the gene CD8A and hepatocellular carcinoma.