Gal-3 levels were negatively correlated with Aβ42/Aβ40 ratio (rho = − 0.285, P = 0.0004, Fig. 6a) in the whole cohort as well as in the NC (rho = − 0.406, P = 0.0141) and AD patient (rho = − 0.187, P = 0.0451) sub-groups (Fig. 6b, c). Here, LGALS3 is linked to Alzheimer disease.