Similarly, CSF Gal-3 positively correlated with t-tau (rho = 0.393, P < 0.0001) in the whole cohort and separately in the AD cohort (rho = 0.271, P = 0.003) and the NC group (rho = 0.375, P = 0.024) (Fig. 6g–i). This evidence concerns the gene LGALS3 and Alzheimer disease.