Aside from the abovementioned mechanisms linking ALS with RBP mislocalization, we hypothesized that a C9orf72-specific mechanism could be at play, as HNRNPK mislocalization in C9orf72 ALS could be instigated by the direct interaction with cytoplasmic RNA foci and/or soluble repeat RNA. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.