More specifically, some HNRNPs were shown to be involved not only in general ALS mechanisms, such as the HNRNP family member and aggregation-prone TAR DNA-binding protein 43 (TDP-43) [58], but also to be relevant in familial ALS, including HNRNPA3 in C9orf72 ALS [47]. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.