VEGFA and cancer: Indeed, the real-time quantitative PCR results showed that Lon and VEGF-A were induced in THP-1 (Fig. 4C) and RAW264.7 (Fig. 4D) macrophage cells under the treatment with media from Lon-overexpressing cancer cells, and Fc-VFD showed repressive effects on the induction in VEGF-A expression in macrophages (Fig. 4C and D).