Previous reports have forecasted the cancer‐related mutations in the genome of SMC5, an irreplaceable molecular of SMC5/6 complex, which contains a heterodimer composed of SMC5 and SMC6, as well as six non‐SMC elements (NSMCE1_NSMCE4A, SLF1, and SLF2).17, 18. The gene discussed is SMC5; the disease is cancer.