Furthermore, in OXA‐treated CRC cells, the mRNA levels of SMC6, NSMCE4A, SLF1, and SLF2 changed similarly to SMC5 (Figure 4D,E), while NSMCE1, NSMCE2, and NSMCE3 changed insignificantly (Figure 4D,E), suggesting that the effect of SMC5 on CRC cells may be mediated through the whole SMC5/6 complex. This evidence concerns the gene NSMCE3 and colorectal carcinoma.