The mRNA level of SMC5 was significantly downregulated in CRC (colon adenocarcinoma (COAD), rectal adenocarcinoma (READ), cecum adenocarcinoma (CEAD), and restosigmoid adenocarcinoma (RESAD)) compared to the normal tissues (colon and rectum) based on sample types (Figure 2A,B) and individual cancer stages (Figure 2C,D). The gene discussed is SMC5; the disease is rectum adenocarcinoma.