In our current study, the interplay of relationships between TH, adiponectin and BAT can be summarized by our key findings: 1) adiponectin level was lower in a hyperthyroid state, 2) FT4 is a predictor for adiponectin level and 3) BAT activity protects against significant metabolic changes in the correction of thyrotoxicosis. Here, ADIPOQ is linked to thyrotoxicosis.