MARCKSL1 and esophageal squamous cell carcinoma: Importantly, in line with previous reports,20 which showed that MARCKSL1 modulates the epithelial‐mesenchymal transition (EMT) by affecting the expression of EMT‐associated proteins, RNA‐seq analysis also indicated that knockdown of MARCKSL1 significantly facilitated the epithelial phenotype (Figure 3H); for instance, depletion of MARCKSL1 markedly promoted the apical junction of ESCC cells.