Among them, KuA has been shown to have strong antioxidant activity, which can significantly attenuate hydrogen peroxide (H2O2)-induced apoptosis in TAR DNA-binding protein 43 (TDP-43)-induced neuroblastoma (SH-SY5Y) cells by inhibiting oxidative stress and inactivating apoptosis signaling pathway12. The gene discussed is TARDBP; the disease is neuroblastoma.