In recent years, many studies have found that TNFRSF9/TNFSF9 is involved in immune regulation of various tumors, including pancreatic cancer and hepatocellular carcinoma (Glorieux and Huang, 2019; Wang et al., 2010), but their specific role in tumor development has not been clarified. This evidence concerns the gene TNFRSF9 and pancreatic neoplasm.