In recent years, many studies have found that TNFRSF9/TNFSF9 is involved in immune regulation of various tumors, including pancreatic cancer and hepatocellular carcinoma (Glorieux and Huang, 2019; Wang et al., 2010), but their specific role in tumor development has not been clarified. Here, TNFRSF9 is linked to hepatocellular carcinoma.