CD8A and systemic lupus erythematosus: Additionally, Draborg et al. reported a significantly reduced amount of activated (CD69+) T cells (CD4 and CD8) and the production of IFN-γ after ex vivo stimulation with EBNA-1 or early diffuse antigen (EBV-EA/D) in SLE patients, indicating that SLE patients have less EBV-specific T cells compared to controls, or that the EBV-specific T cells of SLE patients are not activated after stimulation with EBV antigens [111].