There are sex differences in the responses of lymphocytes to myelin peptides (myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and proteolipid protein (PLP)), where, on the one hand, women with MS show responses that are biased by IFN-γ (Th1), with T cell-mediated demyelination, and on the other hand, men with MS show responses that are biased by IL-5, which may predispose towards more destructive antibody-mediated demyelination [68]. The gene discussed is MOG; the disease is myeloid sarcoma.