The autoimmune response in SLE may be due to the EBNA-1 antigen showing molecular mimicry with common lupus antigens (including Ro, Sm B/B′, and Sm D1), because the EBNA-1 antibodies cross-react with dsDNA or with the spliceosomal protein, Sm [103,104,128,129,130]. The gene discussed is CALR; the disease is systemic lupus erythematosus.