However, it should be added that the development of EBV-associated neoplasms may not only be associated with the “ancestral” MHC-II alleles, but also with certain MHC class I alleles, since, with the exception of cells with EBV latency I, the rest of the latency types of this virus are controlled by cytotoxic CD8 T cells [15,17,18]. This evidence concerns the gene CD8A and neoplasm.