IL10 and type 1 diabetes mellitus: Moreover, IL-10-mediated autoreactivity is frequently detected in T1D patients’ siblings who are AAb negative and that have a very low risk of developing diabetes [203,204]; that is, antibody-negative first-degree relatives have a balance of proinflammatory and regulatory T cells, suggesting that even a moderate regulatory response may be sufficient to prevent the development of clinical T1D in genetically predisposed individuals [204].