CD4 and myeloid sarcoma: Furthermore, unlike the predominant lesion pattern III of MS, with the infiltration of Th1-responding T cells, the pattern II of MS is characterized by antibody/additive-associated demyelination and an accumulation of Th2-responding CD4 T cells that assist B cells in antibody production, along with few Th1-responding T cells, which may also contribute to the humoral response by promoting B cell activation [166,167,168].