EBNA-1-specific CD4 T cells with myelin cross-reaction produce IFN-γ, but they differ from EBNA-1 monospecific CD4 T cells in their ability to produce interleukin-2, indicative of a polyfunctional phenotype, as found in chronic HIV-1 or controlled EBV viral infections [41]. The gene discussed is CD4; the disease is viral infectious disease.