Since EBV was transferred to a hominid ancestor approximately 12 million years ago, and as the DRB1*04, *03, and *02 lineages are the oldest [32], it may be thought that those individuals with the DR2-DQ6, DR3-DQ2, or DR4-DQ8 haplotypes—against which, the immune evasion mechanisms of this virus have evolved the most—may be less resistant to the infection, and have a greater risk of developing EBV-associated diseases. This evidence concerns the gene HLA-DRB1 and infection.