They evaluated the expression of proinflammatory cytokines TNF-α and IL-6 after 3 days, even thougth the histological analysis revealed that the polyurethanes did not showed an inflammatory reaction, and the study of these cytokines revealed that the incorporation of mupirocin in the matrix will induce infection and it could delay the wound-healing process, in comparison with the polyurethane alone. Here, TNF is linked to infection.