Aiming to further clarify the reasons behind reported differences in the association of perilipin polymorphisms with obesity and obesity-related parameters, we analyzed the most commonly studied SNPs in PLIN1 (11482G > A (rs894160), 14995A > T (rs1052700), and 13041A > G (rs2304795)) and the SNP in PLIN2 Ser251Pro (rs35568725), causing a missense mutation in exon 6, in a cohort of prepubertal children showing significant differences in plasma leptin concentration between boys and girls [30]. The gene discussed is PLIN1; the disease is obesity due to melanocortin 4 receptor deficiency.