However, it is important to remember that only about 50% of humans with obesity and insulin resistance ever become clinically diabetic after losing glycemic control, presumably because their GLoad never fully compromises their individual genetic ability to produce enough insulin, however minimal, and thereby they are able to metabolize the glucose burden consumed during daily fasting intervals [70,71,72]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.