Therefore, the increased levels of PBLD, FAM3D, KRT8, SULT2B1, GPA33, DEPTOR, and decreased expression of ACSL4, IFITM1 and HSD11B1 caused by mEVs has been demonstrated to attenuate colitis, implying that consumption of mEVs has the potential to improve intestinal health. The gene discussed is ACSL4; the disease is colitis.