Therefore, the increased levels of PBLD, FAM3D, KRT8, SULT2B1, GPA33, DEPTOR, and decreased expression of ACSL4, IFITM1 and HSD11B1 caused by mEVs has been demonstrated to attenuate colitis, implying that consumption of mEVs has the potential to improve intestinal health. This evidence concerns the gene FAM3D and colitis.