UCP1 and pancreatic neoplasm: Consistent with the observations in cell culture assays, IHC staining of adipose tissue samples collected from tumor-bearing mice at 1, 2 and 3 weeks after tumor inoculation confirmed the browning of white adipocytes taking place in mice with pancreatic cancer, while the UCP1 expression level increased gradually with the progression of pancreatic cancer (Figure 2D–E).