To examine whether the browning of white adipocytes regulated by UCP1 and p38 plays a role in the development of CAC, we first performed the Western blotting and IHC analyses to determine the expression level of UCP1 and phosphorylated p38 (p-p38) and their changes in the in vitro cell culture assay with primary white adipocytes growing in the cancer cell-conditioned medium (Supplementary Figure S1B). This evidence concerns the gene UCP1 and cancer.