IL6 and cancer: Considering multiple cell signaling factors, such as interleukin-6 and tumor necrosis factor-α, which are involved in the interplay between adipose tissue remodeling and metabolic changes in cancer patients [17], our investigation in vitro was performed with a cell culture assay using white adipocytes cultured with cancer-conditioned medium obtained from growing pancreatic cancer cells to provide various cancer-cell-secreted factors.