Furthermore, the sensitivities of HMGB3 for diagnosing lung cancer were improved by over 40% when combined with traditional protein biomarkers such as CEA, CA125, or CYFRA21-1, suggesting that the utilization of autoantibodies to diagnose cancer should be combined with other approaches to improve sensitivity and test characteristics, which can increase both diagnostic utility and reliability [64]. This evidence concerns the gene HMGB3 and lung carcinoma.