Our results are in agreement with the work of Kim and co-workers, where they showed that the infection of their 3D intestinal model of Caco-2 monocultures with Salmonella typhimurium was restricted to the crypt region of the scaffold devoid of mucus and when they suppressed the MUC17 expression, the invaded bacteria increased by 10-fold, penetrating both in the crypts and in the villi [16]. This evidence concerns the gene MUC17 and infection.