Interestingly, the downstream signaling pathways of EGCG–67LR have been demonstrated to alter the structure/function of lipid rafts and thus modulate the endocytosis process; the interaction of EGCG and 67LR induced activation of the protein kinase B (PKB; Akt)/endothelial nitric oxide synthase (eNOS)/ nitric oxide (NO)/ soluble guanylyl cyclase (sGC)/ cyclic guanosine monophosphate (cGMP) pathway, which has been shown to increase membrane fluidity and apoptosis in several cancer cell models [24]. This evidence concerns the gene NOS3 and cancer.