A study that evaluated control patients (who did not have cardiovascular disease), patients with LV hypertrophy without HF, and patients with diastolic HF and LV hypertrophy, showed that the dosage of MMP-2 and procollagen III N-terminal propeptide (PIIINP) together, were shown to be biomarkers that predict HFpEF better than NT-proBNP dosing alone [45]. The gene discussed is MMP2; the disease is cardiovascular disorder.