Clinical studies evaluating the effects of statins on MMP-2 inhibition (atorvastatin, rosuvastatin and pravastatin) in patients with HFrEF after acute myocardial infarction showed decreased serum MMP-2 levels associated with a reduction in the number of deaths and hospital readmission [102,103,104]. This evidence concerns the gene MMP2 and acute myocardial infarction.