This activity is associated with the upregulation of interferon-gamma (IFN-γ), tumor necrosis factor (TNF-α), and the cytokines IL-12 and IL-18, but also with the reduction in the dendritic cell association of allogeneic T-cell proliferation and the downregulation of Interferon-α (IFN-α), cytokines such as IL-4, IL-2, IL-10 and nitric oxide (NO), related to allergic reactions [8]. This evidence concerns the gene TNF and allergic disease.