ANXA2 and COVID-19: A proteomic analysis of clinical samples obtained from COVID-19 patients indicated that major ECM components, including heparan sulfate proteoglycans, collagen VI, laminins, annexin A2, and fibronectin, were diminished in the COVID-19 lungs and may thus be the reason for the impaired elasticity of the bronchial wall, bronchial epithelial cell attachment, and overall alveolus functionality [42].